Acelity V.A.C.ULTA Manual Del Usuario página 15

Animal studies were conducted in healthy, juvenile pigs in order to measure wound fill and
granulation tissue thickness. Full thickness excisional wounds were created on each animal (four
wounds on each side of the spine) and sterile dressings were applied on surgery day 0, following
creation of the wounds. On day 0, paired wounds with the same dressing were treated with either
negative pressure wound therapy (NPWT) at -125 mmHg continuous or instillation therapy (each
cycle consisting of instillation of 20 mL saline, soak time of five minutes, followed by 150 minutes
of NPWT at -125 mmHg continuous). After seven days of continuous therapy, interrupted only
for dressing changes on days three and five, wound fill volume was measured using a saline fill
method, and granulation tissue thickness was determined from stained, formalin-fixed wound
tissue samples, with the following results:
Property
Granulation Thickness
Saline instillation therapy
NPWT
Wound Fill Volume
Saline instillation therapy
NPWT
This data indicates that V.A.C VeraFlo Cleanse™ Dressing has increased mechanical strength and
provides a less robust granulation tissue response in swine. It is uncertain how swine data may
correlate to human results.
NOTE: Never place any foam dressing into blind / unexplored tunnels.
V.A.C. VeraFlo Cleanse™ Dressing can be used when transitioning from V.A.C. VeraFlo™ Therapy
to V.A.C. ® Therapy.
Result
V.A.C. VeraFlo Cleanse™ Dressing generated
24% less granulation tissue
than V.A.C. VeraFlo™ Dressing.
V.A.C. VeraFlo Cleanse™ Dressing generated
30% less granulation tissue
than V.A.C. VeraFlo™ Dressing.
V.A.C. VeraFlo Cleanse™ Dressing generated
27% less wound fill
than V.A.C. VeraFlo™ Dressing.
V.A.C. VeraFlo Cleanse™ Dressing generated
35% less wound fill
than V.A.C. VeraFlo™ Dressing.
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